Prof. Dr. Anette Preiss
April 1994 until March 2022:
Holder of the Chair of General Genetics including Head of the Genetics Institute until 2020, i.e. until the founding of the Institute of Biology.
Activities at the University of Hohenheim:
1997-2000 Dean of the former Faculty II Biology; 2000-2002 and 2014 member of the Senate, 2002-2008 member of the University's Structural Commission and 2015-2021 member of the University Council.
Research:
Our research focused on the developmental genetics of the model system Drosophila melanogaster (fruit fly). This poses the question of which genes control the development of the organism or its organs and how they do this. Research focused on the regulation of the Notch signaling pathway, which controls cellular differentiation, e.g. of stem cells, in a wide variety of tissues and influences cell division and programmed cell death. In a lively exchange with international working groups, we investigated the structure, function and evolution of the factors involved and researched the network of other, previously unknown members. In the meantime, the focus has expanded to include the genomic resilience of Drosophila.
Some important publications from the field of general genetics:
Frankenreiter, L., Gahr, B.M., Schmid, H., Zimmermann, M., Deichsel, S., Hoffmeister, P., Turkiewicz, A., Borggrefe, T., Oswald, F., Nagel, A.C. (2021). Phospho-site mutations in transcription factor Suppressor of Hairless impact Notch signaling activity during haematopoiesis in Drosophila. Frontiers Cell Dev. Biol. 9:658820
Wolf, D., Smylla, T.K., Reichmuth, J., Hoffmeister, P., Kober, L., Zimmermann, M., Turkiewicz, A., Borggrefe, T., Nagel, A. C., Oswald, F., Preiss, A., Maier, D. (2019). Nukleo-cytoplasmatisches Shuttling des Drosophila Hairless-Proteins als Mittel zur Regulation der Notch-Signalübertragung. Biochim Biophys Acta (BBA) Mol. Cell Res. 1866(10):1520-1532
Praxenthaler, H., Nagel, A.C., Schulz, A., Zimmermann, M., Meier, M., Schmid, H., Preiss, A., Maier, D. (2017). Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless. PLoS Genetics 13(5):e1006774
Yuan, Z., Praxenthaler, H., Tabaja, N., Torella, R., Preiss, A., Maier, D., Kovall, R.A. (2016). Structure-function of the Su(H)-Hairless repressor complex, the major antagonist of Notch signaling in D. melanogaster. PLoS Biology 14(7): e100250
Fischer, P., La Rosa, M., Preiss A., Nagel, A.C. (2015). Cyclin G fungiert als positiver Regulator von Wachstum und Stoffwechsel in Drosophila. PLoS Genetics 11(8):e1005440.
arišić, S., Nagel, A., Franz-Wachtel, M., Macek, B., Preiss, A., Link, G., Maier, D., Hausser, A. (2011). Die Phosphorylierung von Serin 402 hemmt die Aktivität der Slingshot 1 (SSH1) Phosphatase. EMBO Rep. 12:527-533
Maier, D., Kurth, P., Schulz, A., Russell, A., Yuan, Z., Gruber, K., Kovall, R.A., Preiss, A. (2011). Strukturelle und funktionelle Analyse des Repressor-Komplexes im Notch-Signalweg von D. melanogaster. Mol. Biol. Cell. 22: 3242-3252
Protzer, C., Preiss, A., Nagel, A.C. (2009). Drosophila α-1,4-Glykosyltransferase α -4GT1 hemmt Reaper-vermittelte Apoptose im Auge. Cell Tiss. Res. 336. 137-147
Nagel, A.C., Krejci, A.,Tenin, G., Bravo-Patiño, A., Bray, S., Maier, D., Preiss, A. (2005). Die durch Hairless vermittelte Unterdrückung von Notch-Zielgenen erfordert die Zusammenarbeit zwischen Groucho und CtBP Co-Repressoren. Mol. Cell Biol. 25(23): 10433-10441
Maier, D., Nagel, A.C., Preiss, A. (2002). Zwei Isoformen des Notch-Antagonisten Hairless werden durch unterschiedliche Translationsinitiierung erzeugt. Proc. Natl. Acad. Sci USA 99:15480-15485
Morel, V., Lecourtois, M., Massiani, O., Maier, D., Preiss, A., Schweisguth, F. (2001). Transkriptionsunterdrückung durch Suppressor of Hairless beinhaltet die Bindung eines Hairless-dCtBP-Komplexes in Drosophila. Curr. Biol. 11: 789-792
Maier, D., Marquart, J., Thompson-Fontaine, A., Beck, I., Wurmbach, E., Preiss, A. (1997).In vivo Struktur-Funktions-Analyse von Drosophila Hairless. Mech. Dev. 67: 97-106
Jennings, B., Preiss, A., Delidakis, C., Bray, S. (1994). Der Notch-Signalweg ist für die Expression des Enhancer of split bHLH-Proteins während der Neurogenese im Drosophila-Embryo erforderlich. Entwicklung 120: 3537 - 3548